Dr. Ma. Noel Alvarez

Dr. Alvarez studies the formation of free radicals by activated macrophages and its role as possible effector molecules on target cells. Her work require the development of suitable methods for the detection and quantification of reactive species generated by inflammatory cells.

Dr. Carlos Batthyány

Associated Professor of the Department of Biochemistry since 2012, Investigator at the Analytical Biochemistry and Proteomics Unit, Institut Pasteur de Montevideo & Academic Coordinator, Programa para la Investigación Biomédica, Facultad de Medicina, Universidad de la República, Uruguay.

Dr. Sebastián Carballal

Sebastián Carballal is an Assistant Professor since 2007. He is currently doing his postgraduate studies centered in the biochemical characterization of cistathionine β-synthase, studying its interaction with reactive oxygen species.

 

Dr. Andrea Medeiros

I have been working in Biochemistry Department since 1997 where I have done my doctoral thesis and postdoctoral work. The proposal of investigation that I am developing constitutes the centre of my activity in the frame of my total dedication as an assistant teacher. It is framed in the "O- glycosylation study applied to cancer and parasitic illnesses”.

     The expression of antigens produced by incomplete O-glycosylation is one of the more notorious alterations in tumoral cells. In the last years, the group of investigation where I work, directed by Dr. Osinaga, has found that these tumor associated antigens are also expressed in different types of parasites. Taking into account the incidences of breast and colorectal cancer in Uruguay, the central subject of my activities consists in the investigation of the immune response that O-glycosylated antigens of parasitic origin can cause in cancer animal models (breast and colon) and this is the general objective of the FCE project that I direct. We are studying the immune response produced by rats immunized with M. vogae and T. cruzi glycoproteins.

 

Dr. Dolores Piñeyro

Dr. Piñeyro is an assistant profesor of the department with teaching functions in the Schools of Medical Technology and in the Basic Cycle.

As a researcher, her work involves the study of the adaptative response of T. cruzi to oxidative stress. In this subject a structural and functional characterization of triparedoxin peroxidases, enzymes that detoxify hydrogen peroxide and peroxynitrite, is being done.

 

Dr. Adriana Cassina

Dr. Adriana Cassina is an expert in mitochondrial oxidative metabolism. Her work is centered in the detection of mitochondrial-derived free radicals and the formation of mitochondrial reactive species in pathologies such as septic shock and neurodegenerative diseases.

 


Dr. Lucía Piacenza

Dr. Piacenza develops studies about the role of nitric oxide and poliamines in the development of programmed cell death in eukariotes and the existence of enzymatic antioxidant systems in parasites.

 

 

 

Dr. Celia Quijano

Dr Quijano studies the formation and reactions of superoxide, nitric oxide and peroxynitrite in endothelial cells in hyperglycemic conditions. She studies, as well, nitration mechanisms of tyrosine in biological systems.

 

Dr. Madia Trujillo

Dr. Trujillo studies the enzymatic and non-enzymatic mechanisms of decomposition of reactive oxygen and nitrogen species at a biological level, as well as the routes that lead to nitration of different biomolecules, particularly proteines. She is now focusing in studying the rol of peroxyredoxins in the anioxidant metabolism of Micobacterium tuberculosis

 

Dr. Andrés Trostchansky

Dr Trostchansky is an Associatedt Professor since 2010. His research activities involve synthesis, detection and chemical and biological characterization of new nitrated lipids derived from free and sterified fatty acids.

 

Former Professor

Dr. Gonzalo Peluffo

(1970-2015)

Dr Peluffo studied L-arginine metabolism and polyamines and nitric oxide formation in eukaryote cells, includind vascular cells. He develops HPLC techniques for detection of free radical formation biomarkers in cells and tissues. He now approaches the study of nitric oxide synthesis alterations in humans.

 

 

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